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Wadleigh Clough is the son of Moses Clough (1742-1829) and Mary (Molly) Cram (c1750-1824). His siblings were Sally Clough (1768-1857), Miriam Clough, Polly Clough, Deborah Clough (1780-?), Moses Clough (1782-?), Hannah Clough (1787-?).