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Polly Clough is the daughter of Moses Clough (1742-1829) and Mary (Molly) Cram (c1750-1824). Her siblings were Sally Clough (1768-1857), Wadleigh Clough, Miriam Clough, Deborah Clough (1780-?), Moses Clough (1782-?), Hannah Clough (1787-?).